The LOXL3 Polyclonal Antibody (PAC019954) is a valuable tool for researchers studying LOXL3, a member of the lysyl oxidase family of enzymes involved in extracellular matrix remodeling and crosslinking of collagen and elastin fibers. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human LOXL3 samples, making it suitable for use in Western blot applications.LOXL3 is known to play a crucial role in maintaining tissue integrity and function through its involvement in the formation and stabilization of the extracellular matrix. Dysregulation of LOXL3 has been implicated in various pathological conditions, including fibrosis, cancer, and cardiovascular diseases.
By targeting LOXL3 with this antibody, researchers can gain insights into its expression levels and activity in different cell types, offering valuable information for studies in the fields of tissue remodeling, cancer biology, and fibrotic disorders.Overall, the LOXL3 Polyclonal Antibody is a reliable tool for investigating the role of LOXL3 in health and disease, providing researchers with the means to explore its functions and potential as a therapeutic target in various pathological conditions.
Antibody Name:
LOXL3 Antibody (PACO19954)
Antibody SKU:
PACO19954
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human LOXL3
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19954(LOXL3 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid, sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Alternatively spliced transcript variants of this gene have been reported but their full-length nature has not been determined.
Synonyms:
lysyl oxidase-like 3
UniProt Protein Function:
LOXL3: a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Alternatively spliced transcript variants of this gene have been reported but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
UniProt Protein Details:
Protein type:Secreted; EC 1.4.3.-; Secreted, signal peptide; Oxidoreductase
Chromosomal Location of Human Ortholog: 2p13
Cellular Component: extracellular region; nucleus
Molecular Function:protein binding
Biological Process: epithelial to mesenchymal transition; negative regulation of transcription, DNA-dependent
NCBI Summary:
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Alternatively spliced transcript variants of this gene have been reported but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
