Loxl2 Antibody (PACO27997)
- SKU:
- PACO27997
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Loxl2 Antibody (PACO27997)
The LOXL2 Polyclonal Antibody (PAC02797) is a powerful tool for researchers studying LOXL2, an enzyme involved in extracellular matrix remodeling and implicated in various diseases, including cancer and fibrosis. This antibody, produced in rabbits, exhibits high specificity for LOXL2 in human samples and is validated for use in Western blot and immunohistochemistry applications.LOXL2, a member of the lysyl oxidase family, plays a critical role in collagen cross-linking and tumor progression by promoting cell migration and invasion. Its overexpression has been linked to poor prognosis in cancer patients, making it a promising target for therapeutic intervention.
The LOXL2 antibody enables precise detection and quantification of LOXL2 levels in different cell types, providing valuable insights for research in cancer biology and tissue remodeling. By understanding the function and regulation of LOXL2, researchers can uncover new therapeutic strategies for treating cancer and fibrotic diseases. The LOXL2 Polyclonal Antibody is a reliable tool for investigating the intricate roles of LOXL2 in disease pathogenesis and developing targeted therapies to improve patient outcomes.
| Antibody Name: | Loxl2 Antibody (PACO27997) |
| Antibody SKU: | PACO27997 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
| Species Reactivity: | Mouse, Human |
| Immunogen: | Recombinant Mouse Lysyl oxidase homolog 2 protein (26-776AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: Loxl2 antibody at 14µg/ml Lane 1: 293T whole cell lysate Lane 2: A549 whole cell lysate Lane 3: A431 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 88, 82 kDa Observed band size: 88 kDa . |
| Background: | Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated Lys-4 of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E-cadherin, probably by mediating deamination of histone H3 By similarity. Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation. |
| Synonyms: | Lysyl oxidase homolog 2 (EC 1.4.3.13) (Lysyl oxidase-like protein 2), Loxl2 |
| UniProt Protein Function: | LOXL2: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E- cadherin, probably by mediating deamination of histone H3. Also involved in E-cadherin repression following hypoxia, a hallmark of epithelial to mesenchymal transition believed to amplify tumor aggressiveness, suggesting that it may play a role in tumor progression. Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation. Belongs to the lysyl oxidase family.Protein type: Cell adhesion; EC 1.4.3.13; Secreted; Secreted, signal peptide; OxidoreductaseCellular Component: basement membrane; chromosome; extracellular region; extracellular space; membrane; nucleoplasm; nucleus; proteinaceous extracellular matrixMolecular Function: chromatin binding; copper ion binding; metal ion binding; methylated histone residue binding; oxidoreductase activity; oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor; protein-lysine 6-oxidase activity; scavenger receptor activity; transcription corepressor activityBiological Process: chromatin modification; collagen fibril organization; endothelial cell migration; endothelial cell proliferation; epithelial to mesenchymal transition; histone modification; negative regulation of transcription, DNA-dependent; positive regulation of chondrocyte differentiation; protein amino acid deamination; protein modification process; regulation of transcription, DNA-dependent; response to copper ion; response to hypoxia; sprouting angiogenesis; transcription, DNA-dependent |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P58022 |
| NCBI GenInfo Identifier: | 225579028 |
| NCBI Gene ID: | 94352 |
| NCBI Accession: | NP_201582.2 |
| UniProt Secondary Accession: | P58022,Q8BRE6, Q8BS86, Q8C4K0, Q9JJ39 |
| UniProt Related Accession: | P58022 |
| Molecular Weight: | |
| NCBI Full Name: | lysyl oxidase homolog 2 |
| NCBI Synonym Full Names: | lysyl oxidase-like 2 |
| NCBI Official Symbol: | Loxl2Â Â |
| NCBI Official Synonym Symbols: | 1110004B06Rik; 4930526G11Rik; 9430067E15Rik  |
| NCBI Protein Information: | lysyl oxidase homolog 2 |
| UniProt Protein Name: | Lysyl oxidase homolog 2 |
| UniProt Synonym Protein Names: | Lysyl oxidase-like protein 2 |
| Protein Family: | Lysyl oxidase |
| UniProt Gene Name: | Loxl2Â Â |
| UniProt Entry Name: | LOXL2_MOUSE |
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