LOXL1 Rabbit Polyclonal Antibody (CAB10191)
- SKU:
- CAB10191
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | LOXL1 Rabbit Polyclonal Antibody |
SKU: | CAB10191 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 95-370 of human LOXL1 (NP_005567.2). |
Sequence: | RQAP SLPL PGRV GSDT VRGQ ARHP FGFG QVPD NWRE VAVG DSTG MARA RTSV SQQR HGGS ASSV SASA FAST YRQQ PSYP QQFP YPQA PFVS QYEN YDPA SRTY DQGF VYYR PAGG GVGA GAAA VASA GVIY PYQP RARY EEYG GGEE LPEY PPQG FYPA PERP YVPP PPPP PDGL DRRY SHSL YSEG TPGF EQAY PDPG PEAA QAHG GDPR LGWY PPYA NPPP EAYG PPRA LEPP YLPV RSSD TPPP GGER NGAQ QGRL SVGS VYRP NQNG RGLP |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | LOL; LOXL; LOXL1 |
Positive Sample: | HeLa,A375,A-549,BT-474,HT-1080,Mouse lung,Mouse heart,Rat heart,U-87 MG |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted, extracellular space. |
Calculated MW: | 63kDa |
Observed MW: | 80kDa/63kDa |
This gene encodes a member of the lysyl oxidase family of proteins. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyzes the first step in the formation of crosslinks in collagen and elastin. The encoded preproprotein is proteolytically processed to generate the mature enzyme. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Mutations in this gene are associated with exfoliation syndrome.
Purification Method: | Affinity purification |
Gene ID: | 4016 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |