The LOXHD1 Polyclonal Antibody (PACO50778) is a valuable tool for researchers studying LOXHD1, a protein involved in auditory function and hair cell development. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the LOXHD1 protein, this antibody allows for the detection and analysis of LOXHD1 expression in various cell types, making it ideal for studies in auditory biology and genetic disorders related to hearing loss.
LOXHD1 is essential for the proper function of hair cells in the inner ear, playing a critical role in hearing and auditory sensory processing. Mutations in the LOXHD1 gene have been linked to hereditary hearing loss in humans, making it a focus of research in the fields of otology and genetics. Understanding the function of LOXHD1 is crucial for developing therapies to treat hearing disorders and improve quality of life for individuals affected by genetic deafness.
Immunohistochemistry of paraffin-embedded human pancreatic cancer using PACO50778 at dilution of 1:100.
Immunofluorescent analysis of HepG2 cells using PACO50778 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Involved in hearing. Required for normal function of hair cells in the inner ear (By similarity).
Synonyms:
Lipoxygenase homology domain-containing protein 1, LOXHD1
UniProt Protein Function:
Involved in hearing. Required for normal function of hair cells in the inner ear ().
UniProt Protein Details:
NCBI Summary:
This gene encodes a highly conserved protein consisting entirely of PLAT (polycystin/lipoxygenase/alpha-toxin) domains, thought to be involved in targeting proteins to the plasma membrane. Studies in mice show that this gene is expressed in the mechanosensory hair cells in the inner ear, and mutations in this gene lead to auditory defects, indicating that this gene is essential for normal hair cell function. Screening of human families segregating deafness identified a mutation in this gene which causes DFNB77, a progressive form of autosomal-recessive nonsyndromic hearing loss (ARNSHL). Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2010]
