The LOX Rabbit Monoclonal Antibody is a highly specific and sensitive antibody designed for research involving LOX, a key enzyme involved in the crosslinking of collagen and elastin fibers in the extracellular matrix. This antibody, developed using cutting-edge technology, allows for precise detection and analysis of LOX protein levels in various cell types and tissues.LOX plays a crucial role in tissue remodeling, wound healing, and cancer progression. Dysregulation of LOX expression has been implicated in various diseases, including fibrosis, cardiovascular diseases, and cancer. The ability to accurately measure LOX levels using this monoclonal antibody provides researchers with a powerful tool for investigating the role of LOX in disease pathogenesis and developing targeted therapies.
With its high specificity and sensitivity, the LOX Rabbit Monoclonal Antibody is a valuable asset for studies in cancer research, fibrosis, and other diseases where LOX plays a key role. Its versatility in applications such as immunohistochemistry and Western blotting makes it an essential tool for researchers seeking to better understand the mechanisms underlying LOX function and its impact on health and disease.
Product Name:
LOX Rabbit Monoclonal Antibody
SKU:
CAB11504
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 318-417 of human LOX (P28300).
WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Synonyms:
AAT10; LOX
Positive Sample:
293T,A549,Jurkat,Mouse lung,Rat lung,Rat spleen
Conjugate:
Unconjugated
Cellular Localization:
Secreted, extracellular space.
Calculated MW:
47kDa
Observed MW:
56kDa
This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections.
Purification Method:
Affinity purification
Gene ID:
4015
Clone Number:
ARC0624
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using LOX Rabbit mAb (CAB11504) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
