The LOX Polyclonal Antibody (CAB7698) is a valuable tool for researchers studying LOX, a key enzyme involved in extracellular matrix remodeling and tissue repair processes. This antibody, generated in rabbits, exhibits high specificity and sensitivity when detecting LOX in human samples using techniques such as Western blotting.LOX, also known as lysyl oxidase, plays a crucial role in the crosslinking of collagen and elastin fibers, contributing to the structural integrity of tissues and organs. Dysregulation of LOX expression has been implicated in various diseases, including fibrosis, cancer, and cardiovascular disorders.
By targeting LOX with this antibody, researchers can gain insights into its function and potential therapeutic applications in these pathological conditions.The LOX Polyclonal Antibody (CAB7698) is a reliable research tool for investigating the role of LOX in health and disease, paving the way for advancements in the fields of tissue engineering, regenerative medicine, and drug development.
Product Name:
LOX Rabbit Polyclonal Antibody
SKU:
CAB7698
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 300-400 of human LOX (NP_002308.2).
This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections.
Purification Method:
Affinity purification
Gene ID:
4015
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using LOX antibody (CAB7698) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
