Lox Antibody (PACO27985)
- SKU:
- PACO27985
- Product Type:
- Antibody
- Reactivity:
- Rat
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Lox Antibody (PACO27985)
The LOX Antibody (PAC027985) is a valuable tool for researchers studying lysyl oxidase (LOX), an enzyme involved in the crosslinking of collagen and elastin fibers in the extracellular matrix. This polyclonal antibody, raised in rabbits, is highly specific for LOX and has been validated for use in immunohistochemistry and flow cytometry applications.LOX plays a crucial role in tissue remodeling and fibrosis, making it a key player in diseases such as cancer, cardiovascular disease, and pulmonary fibrosis.
By targeting LOX with this antibody, researchers can better understand its role in disease progression and potentially identify new therapeutic targets.Whether investigating LOX expression in tumor tissues or studying its role in tissue repair, the LOX Antibody (PAC027985) is a valuable tool for researchers seeking to unravel the complexities of LOX biology and its implications in various disease states.
| Antibody Name: | Lox Antibody (PACO27985) |
| Antibody SKU: | PACO27985 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
| Species Reactivity: | Rat, Human |
| Immunogen: | Recombinant Rat Protein-lysine 6-oxidas protein (163-411AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: Lox antibody at 2µg/ml + K562 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 47 kDa Observed band size: 47 kDa . |
| Background: | Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. |
| Synonyms: | Protein-lysine 6-oxidase (EC 1.4.3.13) (Lysyl oxidase), Lox |
| UniProt Protein Function: | LOX: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression. Belongs to the lysyl oxidase family.Protein type: EC 1.4.3.13; Oxidoreductase; Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 18q11Cellular Component: collagen; extracellular region; extracellular space; nucleus; proteinaceous extracellular matrixMolecular Function: copper ion binding; protein-lysine 6-oxidase activityBiological Process: blood vessel development; blood vessel morphogenesis; collagen fibril organization; elastic fiber assembly; heart development; lung development; response to drug; response to hormone stimulus; response to steroid hormone stimulus; wound healing |
| UniProt Protein Details: | |
| NCBI Summary: | enzyme involved in the catalysis of the reaction required for cross-linking of collagen and elastin fibers [RGD, Feb 2006] |
| UniProt Code: | P16636 |
| NCBI GenInfo Identifier: | 8393733 |
| NCBI Gene ID: | 24914 |
| NCBI Accession: | NP_058757.1 |
| UniProt Secondary Accession: | P16636 |
| UniProt Related Accession: | P16636 |
| Molecular Weight: | 46,559 Da |
| NCBI Full Name: | protein-lysine 6-oxidase |
| NCBI Synonym Full Names: | lysyl oxidase |
| NCBI Official Symbol: | Lox  |
| NCBI Official Synonym Symbols: | Rrg1; H-rev142Â Â |
| NCBI Protein Information: | protein-lysine 6-oxidase |
| UniProt Protein Name: | Protein-lysine 6-oxidase |
| UniProt Synonym Protein Names: | Lysyl oxidase |
| Protein Family: | Linoleate 9/13-lipoxygenase |
| UniProt Gene Name: | Lox  |
| UniProt Entry Name: |
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