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Lox Antibody (PACO27985)

SKU:
PACO27985
Product Type:
Antibody
Reactivity:
Rat
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339
Frequently bought together:

Description

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Lox Antibody (PACO27985)

The LOX Antibody (PAC027985) is a valuable tool for researchers studying lysyl oxidase (LOX), an enzyme involved in the crosslinking of collagen and elastin fibers in the extracellular matrix. This polyclonal antibody, raised in rabbits, is highly specific for LOX and has been validated for use in immunohistochemistry and flow cytometry applications.LOX plays a crucial role in tissue remodeling and fibrosis, making it a key player in diseases such as cancer, cardiovascular disease, and pulmonary fibrosis.

By targeting LOX with this antibody, researchers can better understand its role in disease progression and potentially identify new therapeutic targets.Whether investigating LOX expression in tumor tissues or studying its role in tissue repair, the LOX Antibody (PAC027985) is a valuable tool for researchers seeking to unravel the complexities of LOX biology and its implications in various disease states.

Antibody Name:Lox Antibody (PACO27985)
Antibody SKU:PACO27985
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:1000-1:5000
Species Reactivity:Rat, Human
Immunogen:Recombinant Rat Protein-lysine 6-oxidas protein (163-411AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern blot
All lanes: Lox antibody at 2µg/ml + K562 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 47 kDa
Observed band size: 47 kDa
.
Background:Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin.
Synonyms:Protein-lysine 6-oxidase (EC 1.4.3.13) (Lysyl oxidase), Lox
UniProt Protein Function:LOX: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression. Belongs to the lysyl oxidase family.Protein type: EC 1.4.3.13; Oxidoreductase; Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 18q11Cellular Component: collagen; extracellular region; extracellular space; nucleus; proteinaceous extracellular matrixMolecular Function: copper ion binding; protein-lysine 6-oxidase activityBiological Process: blood vessel development; blood vessel morphogenesis; collagen fibril organization; elastic fiber assembly; heart development; lung development; response to drug; response to hormone stimulus; response to steroid hormone stimulus; wound healing
UniProt Protein Details:
NCBI Summary:enzyme involved in the catalysis of the reaction required for cross-linking of collagen and elastin fibers [RGD, Feb 2006]
UniProt Code:P16636
NCBI GenInfo Identifier:8393733
NCBI Gene ID:24914
NCBI Accession:NP_058757.1
UniProt Secondary Accession:P16636
UniProt Related Accession:P16636
Molecular Weight:46,559 Da
NCBI Full Name:protein-lysine 6-oxidase
NCBI Synonym Full Names:lysyl oxidase
NCBI Official Symbol:Lox  
NCBI Official Synonym Symbols:Rrg1; H-rev142  
NCBI Protein Information:protein-lysine 6-oxidase
UniProt Protein Name:Protein-lysine 6-oxidase
UniProt Synonym Protein Names:Lysyl oxidase
Protein Family:Linoleate 9/13-lipoxygenase
UniProt Gene Name:Lox  
UniProt Entry Name:
ELISA Kits
Rat Protein-lysine 6-oxidase (Lox) ELISA Kit
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
Recommended Products
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011)
Anti-HRP-conjugated Beta Actin Antibody (CABC028)

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