The LONP2 Polyclonal Antibody (CAB15909) is a high-quality antibody specifically designed for research involving LONP2, a protein responsible for mitochondrial quality control. This antibody, generated in rabbits, is highly reactive and validated for use in various applications, including Western blotting. By binding to the LONP2 protein, this antibody allows for the detection and analysis of LONP2 levels in different cell types.LONP2 is a key player in maintaining mitochondrial function and integrity, making it a crucial protein to study in the context of aging, neurodegenerative diseases, and metabolic disorders.
By understanding the role of LONP2 in mitochondrial quality control, researchers can develop targeted therapies for conditions related to mitochondrial dysfunction.Overall, the LONP2 Polyclonal Antibody (CAB15909) is an essential tool for researchers looking to explore the role of LONP2 in mitochondrial quality control and its implications in various diseases.
Product Name:
LONP2 Rabbit Polyclonal Antibody
SKU:
CAB15909
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human LONP2 (NP_113678.2).
In human, peroxisomes function primarily to catalyze fatty acid beta-oxidation and, as a by-product, produce hydrogen peroxide and superoxide. The protein encoded by this gene is an ATP-dependent protease that likely plays a role in maintaining overall peroxisome homeostasis as well as proteolytically degrading peroxisomal proteins damaged by oxidation. The protein has an N-terminal Lon N substrate recognition domain, an ATPase domain, a proteolytic domain, and, in some isoforms, a C-terminal peroxisome targeting sequence. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Purification Method:
Affinity purification
Gene ID:
83752
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using LONP2 Rabbit pAb (CAB15909) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
