LONP1 Rabbit Polyclonal Antibody (CAB4293)
- SKU:
- CAB4293
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | LONP1 Rabbit Polyclonal Antibody |
SKU: | CAB4293 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-400 of human LONP1 (NP_004784.2). |
Sequence: | VFPH LPLI AITR NPVF PRFI KIIE VKNK KLVE LLRR KVRL AQPY VGVF LKRD DSNE SDVV ESLD EIYH TGTF AQIH EMQD LGDK LRMI VMGH RRVH ISRQ LEVE PEEP EAEN KHKP RRKS KRGK KEAE DELS ARHP AELA MEPT PELP AEVL MVEV ENVV HEDF QVTE EVKA LTAE IVKT IRDI IALN PLYR ESVL QMMQ AGQR VVDN PIYL SDMG AALT GAES HELQ DVLE ETNI PKRL YKAL SLLK KEFE LSKL QQRL GREV EEKI KQTH RKYL LQEQ L |
Tested Applications: | WB IHC-P IF/ICC IP ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | LON; LONP; PIM1; hLON; LonHS; CODASS; PRSS15; LONP1 |
Positive Sample: | A-549,HL-60,LO2,HT-1080,BT-474,Mouse heart,Mouse kidney,Mouse liver,Rat kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Mitochondrion matrix. |
Calculated MW: | 106kDa |
Observed MW: | 106kDa |
This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia (PMID:18378094). Alternatively spliced transcript variants have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 9361 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |