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LMP2 Antibody (PACO52150)

SKU:
PACO52150
Product Type:
Antibody
Reactivity:
Virus
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339
Frequently bought together:

Description

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LMP2 Antibody (PACO52150)

The LMP2 Monoclonal Antibody (PAC052150) is a valuable tool for research involving the LMP2 protein, a component of the immunoproteasome complex. This antibody, produced in mice, is highly specific and reliable for detecting LMP2 in human samples. Validated for use in applications such as Western blot and immunohistochemistry, it enables researchers to study the expression and localization of LMP2 in various cell types and tissues.LMP2 is a key player in antigen processing and presentation, playing a crucial role in adaptive immune responses. Dysregulation of LMP2 has been implicated in various diseases, including autoimmune disorders and viral infections.

By targeting LMP2, researchers can gain insights into the mechanisms of immune response and develop targeted therapies for diseases where antigen presentation is disrupted.The LMP2 Monoclonal Antibody is a powerful tool for studying the function of LMP2 in immune regulation, inflammation, and disease pathogenesis. Its high specificity and sensitivity make it an essential reagent for researchers in the fields of immunology, oncology, and infectious diseases.

Antibody Name:LMP2 Antibody (PACO52150)
Antibody SKU:PACO52150
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:200-1:2000
Species Reactivity:Epstein-Barr virus
Immunogen:Recombinant Epstein-Barr virus Latent membrane protein 2 protein (1-147AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern Blot. Positive WB detected in: Mouse liver tissue, Mouse kidney tissue. All lanes: LMP2 antibody at 2µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 54, 41 kDa. Observed band size: 54 kDa.
Background:Isoform LMP2A maintains EBV latent infection of B-lymphocyte, by preventing lytic reactivation of the virus in response to surface immunoglobulin (sIg) cross-linking. Acts like a dominant negative inhibitor of the sIg-associated protein tyrosine kinases, LYN and SYK. Also blocks translocation of the B-cell antigen receptor (BCR) into lipid rafts, preventing the subsequent signaling and accelerated internalization of the BCR upon BCR cross-linking. Serves as a molecular scaffold to recruit SYK, LYN and E3 protein-ubiquitin ligases, such as ITCH and NEDD4L, leading to ubiquitination and potential degradation of both tyrosines kinases. Possesses a constitutive signaling activity in non-transformed cells, inducing bypass of normal B lymphocyte developmental checkpoints allowing immunoglobulin-negative cells to colonize peripheral lymphoid organs.
Synonyms:Latent membrane protein 2 (Terminal protein), LMP2
UniProt Protein Function:Function: Isoform LMP2A maintains EBV latent infection of B-lymphocyte, by preventing lytic reactivation of the virus in response to surface immunoglobulin (sIg) cross-linking. Acts like a dominant negative inhibitor of the sIg-associated protein tyrosine kinases, LYN and SYK. Also blocks translocation of the B-cell antigen receptor (BCR) into lipid rafts, preventing the subsequent signaling and accelerated internalization of the BCR upon BCR cross-linking. Serves as a molecular scaffold to recruit SYK, LYN and E3 protein-ubiquitin ligases, such as ITCH and NEDD4L, leading to ubiquitination and potential degradation of both tyrosines kinases. Possesses a constitutive signaling activity in non-transformed cells, inducing bypass of normal B lymphocyte developmental checkpoints allowing immunoglobulin-negative cells to colonize peripheral lymphoid organs. Ref.5 Ref.8Isoform LMP2B may be a negative regulator of isoform LMP2A. Ref.5 Ref.8Subunit structure: Isoform LMP2A cytoplasmic N-terminal domain interacts with human SRC family protein tyrosine kinases SYK and LYN. Binds human ITCH, WWP2 and NEDD4L. Ref.6 Ref.9Subcellular location: Isoform LMP2A: Host cell membrane; Multi-pass membrane protein. Note: Isoform LMP2A is localized in plasma membrane lipid rafts. Ref.10 Ref.11Isoform LMP2B: Host endomembrane system; Multi-pass membrane protein. Host cytoplasm › host perinuclear region. Note: Isoform LMP2B localizes to perinuclear regions. Ref.10 Ref.11Post-translational modification: Isoform LMP2A is phosphorylated on cytoplasmic N-terminal tyrosines residues, possibly by human LYN. Ref.4Can be ubiquitinated by human ITCH and WWP2 on the N-terminus in a lysine-independent manner.Miscellaneous: In healthy individuals, EBV typically establishes a persistent latent infection in which the virus can be detected in resting, nonproliferating peripheral B-lymphocytes. These latently infected cells express only 2 virally encoded genes, LMP2A and EBNA1.Sequence similarities: Belongs to the herpesviridae LMP-2 family.
UniProt Protein Details:
NCBI Summary:
UniProt Code:P13285
NCBI GenInfo Identifier:82503189
NCBI Gene ID:3783751
NCBI Accession:YP_401631.1
UniProt Secondary Accession:P13285,Q777H4, Q8AZK9
UniProt Related Accession:P13285,1405236A
Molecular Weight:17.6 kDa
NCBI Full Name:K15
NCBI Synonym Full Names:
NCBI Official Symbol:LMP-2A  
NCBI Official Synonym Symbols:
NCBI Protein Information:K15; LMP-2A
UniProt Protein Name:Latent membrane protein 2
UniProt Synonym Protein Names:Terminal protein
Protein Family:Latent membrane protein
UniProt Gene Name:LMP2  
UniProt Entry Name:LMP2_EBVB9
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