The LMOD3 Polyclonal Antibody (PACO10273) is a valuable tool for research involving LMOD3, a protein involved in actin filament organization and muscle contraction. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the LMOD3 protein, researchers can accurately detect and analyze its expression in various cell types, making it an essential reagent for studies in muscle biology and related fields.LMOD3, also known as Leiomodin 3, plays a crucial role in regulating the assembly of actin filaments in muscle cells, contributing to muscle contraction and function.
Its involvement in actin dynamics makes it a key target for research into muscle disorders, such as myopathies and muscular dystrophies. Understanding the role of LMOD3 in muscle physiology is essential for developing therapies aimed at improving muscle function and treating related diseases.Overall, the LMOD3 Polyclonal Antibody (PACO10273) offers researchers a reliable tool for investigating the role of LMOD3 in muscle biology and related fields, providing valuable insights into muscle function and potential therapeutic targets for muscle disorders.
LMOD3: Belongs to the tropomodulin family. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 3p14.1Cellular Component: striated muscle thin filamentMolecular Function: tropomyosin bindingBiological Process: actin filament organization; muscle contraction; myofibril assemblyDisease: Nemaline Myopathy 10
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the leiomodin family of proteins. This protein contains three actin-binding domains, a tropomyosin domain, a leucine-rich repeat domain, and a Wiskott-Aldrich syndrome protein homology 2 domain (WH2). Localization of this protein to the pointed ends of thin filaments has been observed, and there is evidence that this protein acts as a catalyst of actin nucleation, and is important to the organization of sarcomeric thin filaments in skeletal muscles. Mutations in this gene have been associated as one cause of Nemaline myopathy, as other genes have also been linked to this disorder. Nemaline myopathy is a disorder characterized by nonprogressive generalized muscle weakness and protein inclusions (nemaline bodies) in skeletal myofibers. Patients with mutations in this gene often present with a severe congenital form of the disorder. [provided by RefSeq, Jan 2015]
