The LMNB1 Polyclonal Antibody (CAB16685) is a valuable tool for researchers studying lamin B1, a key protein involved in nuclear organization and stability. This antibody, raised in rabbits, shows high specificity and reactivity towards human samples, making it ideal for use in Western blot applications. By targeting the LMNB1 protein, researchers can accurately detect and analyze its expression in various cell types, providing insights into its role in various cellular processes.
Lamin B1 is a crucial component of the nuclear lamina, playing a role in maintaining nuclear shape, chromatin organization, and gene regulation. Dysregulation of lamin B1 has been linked to various diseases including cancer, progeria, and muscular dystrophy. By using the LMNB1 Polyclonal Antibody, researchers can further explore the functions of lamin B1 and its implications in disease pathogenesis, ultimately leading to potential therapeutic targets for these conditions.
Product Name:
Lamin B1 Rabbit Polyclonal Antibody
SKU:
CAB16685
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 361-460 of human Lamin B1 (NP_005564.1).
Sequence:
EQLL DVKL ALDM EISA YRKL LEGE EERL KLSP SPSS RVTV SRAS SSRS VRTT RGKR KRVD VEES EASS SVSI SHSA SATG NVCI EEID VDGK FIRL KNTS
Tested Applications:
WBIF/ICCIPELISA
Recommended Dilution:
WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
This gene encodes one of the two B-type lamin proteins and is a component of the nuclear lamina. A duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
4001
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Lamin B1 Rabbit pAb (CAB16685) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
