The LMNA Polyclonal Antibody (CAB17319) is a valuable tool for researchers studying lamin A/C, a key protein involved in nuclear structure and regulation. This antibody, produced in rabbits, is highly specific to human samples and is optimized for use in Western blot applications. By targeting the LMNA protein, researchers can study its functions and interactions in various cell types, opening up possibilities for research in fields such as cell biology, cancer research, and aging-related studies.Lamin A/C is essential for maintaining nuclear integrity and plays a crucial role in processes like DNA replication, gene expression, and cell differentiation.
Mutations in the LMNA gene have been linked to diseases such as muscular dystrophy, progeria, and lipodystrophy, making it a significant target for investigative studies. By utilizing the LMNA Polyclonal Antibody, researchers can further explore the roles and mechanisms of lamin A/C, paving the way for potential therapeutic interventions in related disorders.
The protein encoded by this gene is part of the nuclear lamina, a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
Purification Method:
Affinity purification
Gene ID:
4000
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Lamin A/C Rabbit pAb (CAB17319).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).
