The LMAN2L Polyclonal Antibody (CAB18505) is a valuable tool for researchers studying LMAN2L, a protein involved in protein trafficking and glycosylation processes within the cell. This antibody, produced in rabbits, exhibits high specificity and reactivity towards human samples, making it an ideal choice for Western blot applications. By targeting the LMAN2L protein, this antibody enables precise detection and analysis in a variety of cell types, providing insights into its function and role in cellular processes.LMAN2L, also known as lectin, mannose-binding 2-like protein, plays a crucial role in ensuring proper protein folding and trafficking in the endoplasmic reticulum.
Dysregulation of LMAN2L has been linked to diseases such as neurodegenerative disorders, cancer, and metabolic syndromes, highlighting its importance in cellular homeostasis. By studying the function of LMAN2L, researchers can gain a deeper understanding of its involvement in disease pathology and potentially identify novel therapeutic targets for intervention.
Product Name:
LMAN2L Rabbit Polyclonal Antibody
SKU:
CAB18505
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 189-348 of human LMAN2L (NP_110432.1).
COPII-coated ER to Golgi transport vesicle, endoplasmic reticulum-Golgi intermediate compartment, Golgi apparatus
Calculated MW:
40kDa
Observed MW:
40kDa
This gene encodes a protein belonging to the L-type lectin group of type 1 membrane proteins, which function in the mammalian early secretory pathway. These proteins contain luminal carbohydrate recognition domains, which display homology to leguminous lectins. Unlike other proteins of the group, which cycle in the early secretory pathway and are predominantly associated with post endoplasmic reticulum membranes, the protein encoded by this gene is a non-cycling resident protein of the ER, where it functions as a cargo receptor for glycoproteins. It is proposed to regulate exchange of folded proteins for transport to the Golgi and exchange of misfolded glycoproteins for transport to the ubiquitin-proteasome pathway.
Purification Method:
Affinity purification
Gene ID:
81562
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of HeLa cells, using LMAN2L antibody (CAB18505) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
