UniProt Protein Function: | Pasteurella leukotoxins are exotoxins that attack host leukocytes and especially polymorphonuclear cells, by causing cell rupture. The leukotoxin binds to the host LFA-1 integrin and induces a signaling cascade leading to many biological effects, including tyrosine phosphorylation of the CD18 tail, elevation of the intracellular Ca2+ and lysis of the host cell (). This leukotoxin is a major contributor to the pathogenesis of lung injury in ovine pneumonic pasteurellosis. It has also weak hemolytic activity. |
UniProt Protein Details: | |
NCBI Summary: | |
UniProt Code: | P0C085 |
NCBI GenInfo Identifier: | 73621161 |
NCBI Gene ID: | |
NCBI Accession: | P0C085.1 |
UniProt Secondary Accession: | P0C085,Q9EV28 |
UniProt Related Accession: | P0C085 |
Molecular Weight: | 28 kDa |
NCBI Full Name: | Leukotoxin |
NCBI Synonym Full Names: | |
NCBI Official Symbol: | |
NCBI Official Synonym Symbols: | |
NCBI Protein Information: | |
UniProt Protein Name: | Leukotoxin |
UniProt Synonym Protein Names: | |
Protein Family: | Leukotoxin |
UniProt Gene Name: | lktAÂ Â |
UniProt Entry Name: | LKA7B_MANHA |