The LKTA Antibody (PAC034106) is a high-quality rabbit polyclonal antibody designed for researchers studying the LKTA protein. LKTA is a cell surface molecule with implications in immune regulation, specifically inhibiting immune responses. This antibody is highly reactive with human samples and has been validated for use in Western blot applications.By binding to the LKTA protein, this antibody enables researchers to detect and analyze LKTA expression in various cell types, making it ideal for studies in immunology and cancer research.
LKTA, also known as an immune inhibitory receptor, plays a crucial role in immune homeostasis by regulating inflammation and inhibiting allergic reactions.The significance of LKTA in immune response modulation makes it a valuable target for research into diseases like cancer, autoimmune disorders, and chronic inflammatory conditions. Understanding the activity of LKTA is essential for the development of therapies that harness or modulate immune function in these contexts.
Antibody Name:
lktA Antibody (PACO34106)
Antibody SKU:
PACO34106
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Mannheimia haemolytica
Immunogen:
Recombinant Mannheimia haemolytica Leukotoxin protein (715-953AA)
Pasteurella leukotoxins are exotoxins that attack host leukocytes and especially polymorphonuclear cells, by causing cell rupture. The leukotoxin binds to the host LFA-1 integrin and induces a signaling cascade leading to many biological effects, including tyrosine phosphorylation of the CD18 tail, elevation of the intracellular Ca2+ and lysis of the host cell (). This leukotoxin is a major contributor to the pathogenesis of lung injury in ovine pneumonic pasteurellosis. It has also weak hemolytic activity.
