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LITAF Monoclonal Antibody [PAT5C10AT] (CPAB0072)

SKU:
CPAB0072
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2b
Clone:
PAT5C10AT
Applications:
WB
ELISA
€149
Frequently bought together:

Description

system_update_alt Datasheet

LITAF Monoclonal Antibody [PAT5C10AT] (CPAB0072)

The LITAF Polyclonal Antibody (CPAB0072) is a valuable tool for researchers studying the LPS-induced TNF-alpha factor (LITAF) protein. LITAF is known to play a role in immune responses, particularly in the activation of proinflammatory cytokines. This antibody, produced in rabbits, is highly specific and reactive towards human samples, making it ideal for Western blot applications.By binding to the LITAF protein, this antibody allows for the detection and analysis of LITAF expression in various cell types. Its use is particularly beneficial in immunology and cancer research, where understanding LITAF's role in immune regulation and inflammation can lead to insights into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions.

With its high specificity and reactivity, the LITAF Polyclonal Antibody is a valuable tool for researchers looking to delve deeper into the mechanisms of immune response modulation and inflammation, paving the way for potential therapeutic interventions in various disease contexts.

Product Name:LITAF Antibody
Product Sku:CPAB0072
Size:5μg
Host Species:Mouse
Immunogen:Anti-human LITAF mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human LITAF amino acids 1-161 purified from Ecoli.
Clone:PAT5C10AT.
Reactivity:Human
Applications:Western Blot, ELISA
Purification Method:LITAF antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG2b
Background:Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. LITAF is a lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of the LITAF gene is induced by tumor suppressor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in the LITAF gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget''s disease (EMPD).
Synonyms:Lipopolysaccharide-induced tumor necrosis factor-alpha factor, LPS-induced TNF-alpha factor, p53-induced gene 7 protein, Small integral membrane protein of lysosome/late endosome, LITAF, PIG7, SIMPLE, TP53I7, FLJ38636, MGC116698, MGC116700, MGC116701, MGC125274, MGC125275, MGC125276.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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