The Liprin-alpha-1 Polyclonal Antibody (CAB10388) is a valuable tool for researchers studying Liprin-alpha-1, a key protein involved in synapse formation and cell adhesion. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to Liprin-alpha-1, this antibody enables precise detection and analysis of this protein in various cell types, making it ideal for investigations in neuroscience and developmental biology.
Liprin-alpha-1 is known for its critical role in neural development, including synapse organization and dendritic spine formation. By understanding the function of Liprin-alpha-1, researchers can gain insights into neurodevelopmental disorders and synaptic plasticity. This antibody is a valuable tool for uncovering the mechanisms underlying neuronal connectivity and function, with implications for studies on neurological diseases and cognitive processes.
Product Name:
PPFIA1 Rabbit Polyclonal Antibody
SKU:
CAB10388
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 660-800 of human PPFIA1 (NP_003617.1).
The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Purification Method:
Affinity purification
Gene ID:
8500
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PPFIA1 antibody (CAB10388) at 1:5000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
