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LIPI Antibody (PACO22389)

SKU:
PACO22389
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€419
Frequently bought together:

Description

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LIPI Antibody (PACO22389)

The LIPI Polyclonal Antibody (PACO22389) is a valuable tool for researchers studying lipid metabolism and related pathways. This antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting LIPI protein in human samples, making it an ideal choice for applications such as Western blotting.LIPI, also known as Lipase Maturation Factor 1 (LMF1), plays a crucial role in the maturation and activation of lipases involved in lipid metabolism. Dysregulation of LIPI has been linked to metabolic disorders such as obesity and diabetes, making it a promising target for therapeutic interventions.

By using the LIPI Polyclonal Antibody, researchers can gain insights into the functions of LIPI in various cell types and tissues, contributing to a deeper understanding of lipid metabolism and its implications for human health. This antibody is a valuable tool for studies in metabolic disorders, lipid biology, and drug discovery aimed at targeting lipid-related diseases.

Antibody Name:LIPI Antibody (PACO22389)
Antibody SKU:PACO22389
Size:100ul
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:Human
Immunogen:Synthesized peptide derived from internal of human LIPI.
Form:Liquid
Storage Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern blot analysis of extracts from COLO cells, using LIPI antibody.
Background:Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).
Synonyms:EC 3.1.1.-; lipase member I; LPD lipase; LPDL; membrane-associated phosphatidic acid-selective phospholipase A1-beta
UniProt Protein Function:LIPI: Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG). Defects in LIPI may be a cause of susceptibility to familial hypertriglyceridemia (FHTR)[MIM:145750]. Familial hypertriglyceridemia is a common inherited disorder in which the concentration of very low density lipoprotein (VLDL) is elevated in the plasma. This leads to increased risk of heart disease, obesity, and pancreatitis. Belongs to the AB hydrolase superfamily. Lipase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Cancer Testis Antigen (CTA); Secreted, signal peptide; Secreted; Phospholipase; EC 3.1.1.-Chromosomal Location of Human Ortholog: 21q11.2Cellular Component: plasma membraneMolecular Function: heparin binding; phospholipase activityBiological Process: lipid catabolic process; lipid digestionDisease: Hypertriglyceridemia, Familial
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene is a phospholipase that hydrolyzes phosphatidic acid to produce lysophosphatidic acid. Defects in this gene are a cause of susceptibility to familial hypertrigliceridemia. This gene is also expressed at high levels in Ewing family tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
UniProt Code:Q6XZB0
NCBI GenInfo Identifier:81170675
NCBI Gene ID:149998
NCBI Accession:Q6XZB0.2
UniProt Secondary Accession:Q6XZB0,G1JSG3, G1JSG4, G1JSG5, G1JSG6, G1JSG7, G1JSG8 G1JSG9
UniProt Related Accession:Q6XZB0
Molecular Weight:34,110 Da
NCBI Full Name:Lipase member I
NCBI Synonym Full Names:lipase I
NCBI Official Symbol:LIPI  
NCBI Official Synonym Symbols:CT17; LPDL; PLA1C; PRED5; mPA-PLA1 beta  
NCBI Protein Information:lipase member I
UniProt Protein Name:Lipase member I
UniProt Synonym Protein Names:Cancer/testis antigen 17; CT17; LPD lipase; Membrane-associated phosphatidic acid-selective phospholipase A1-beta; mPA-PLA1 beta
Protein Family:Lipase
UniProt Gene Name:LIPI  
UniProt Entry Name:LIPI_HUMAN
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