The LIPI Antibody (PACO01028) is a polyclonal antibody designed for research involving LIPI, a key protein involved in lipid metabolism and associated with various metabolic disorders. The antibody, produced in rabbits, is highly specific and reactive with human samples, making it a valuable tool for studies in biochemistry and metabolism research.LIPI, also known as Lipase Protein, plays a critical role in lipid digestion and absorption, making it a vital target for understanding lipid metabolism and its implications in conditions like obesity, diabetes, and cardiovascular diseases.
By detecting and analyzing LIPI protein levels in various cell types, researchers can gain insights into the mechanisms underlying lipid metabolism and potentially identify new therapeutic targets.The LIPI Antibody (PACO01028) is validated for use in Western blot applications, providing researchers with a reliable means of detecting LIPI protein expression in experimental settings. Its high specificity and sensitivity make it an ideal choice for studies investigating the role of LIPI in metabolic disorders and potential therapeutic interventions.
Antibody Name:
LIPI Antibody
Antibody SKU:
PACO01028
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human LPD lipase.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
LIPI: Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG). Defects in LIPI may be a cause of susceptibility to familial hypertriglyceridemia (FHTR)[MIM:145750]. Familial hypertriglyceridemia is a common inherited disorder in which the concentration of very low density lipoprotein (VLDL) is elevated in the plasma. This leads to increased risk of heart disease, obesity, and pancreatitis. Belongs to the AB hydrolase superfamily. Lipase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Cancer Testis Antigen (CTA); Secreted, signal peptide; Secreted; Phospholipase; EC 3.1.1.-Chromosomal Location of Human Ortholog: 21q11.2Cellular Component: plasma membraneMolecular Function: heparin binding; phospholipase activityBiological Process: lipid catabolic process; lipid digestionDisease: Hypertriglyceridemia, Familial
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a phospholipase that hydrolyzes phosphatidic acid to produce lysophosphatidic acid. Defects in this gene are a cause of susceptibility to familial hypertrigliceridemia. This gene is also expressed at high levels in Ewing family tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
