The LINGO1 Polyclonal Antibody (CAB9369) is a valuable tool for researchers interested in studying LINGO1, a protein involved in regulating neuronal development and myelination in the central nervous system. This antibody, derived from rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By selectively binding to the LINGO1 protein, this antibody enables researchers to detect and analyze LINGO1 expression in various cell types, making it an excellent choice for studies in neuroscience and neurology.LINGO1, a key regulator of neuronal growth and myelination, plays a crucial role in shaping the structure and function of the nervous system.
Dysregulation of LINGO1 has been implicated in neurological disorders such as multiple sclerosis, Alzheimer's disease, and Parkinson's disease, highlighting its potential as a therapeutic target. Investigating the functions of LINGO1 can provide valuable insights into the mechanisms underlying these conditions and may lead to the development of novel treatment strategies aimed at modulating neuronal growth and myelination.
Product Name:
LINGO1 Rabbit Polyclonal Antibody
SKU:
CAB9369
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 42-240 of human LINGO1 (NP_116197.4).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
70kDa
Observed MW:
70kDa
Predicted to enable epidermal growth factor receptor binding activity. Predicted to act upstream of or within generation of neurons and protein kinase B signaling. Predicted to be located in plasma membrane. Predicted to be active in extracellular matrix and extracellular space. Implicated in autosomal recessive non-syndromic intellectual disability and glaucoma.
Purification Method:
Affinity purification
Gene ID:
84894
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using LINGO1 antibody (CAB9369) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
