The LIN7B Polyclonal Antibody (PAC010260) is a valuable tool for researchers studying the LIN7B protein, a key player in cell signaling and protein trafficking processes. This antibody, derived from rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the LIN7B protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an essential component in studies related to cell biology, signal transduction, and disease mechanisms.LIN7B is a scaffold protein known for its ability to interact with multiple binding partners involved in cell polarity, synaptic function, and membrane protein trafficking.
Its role in organizing protein complexes and regulating intracellular signaling pathways highlights its importance in various physiological processes. Research on LIN7B is crucial for understanding its function in health and disease, including neurological disorders, cancer progression, and developmental abnormalities. By targeting LIN7B, researchers can gain insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets for intervention.
lin-7 homolog B (C. elegans);LIN7B;LIN-7B;MALS-2;MALS2;VELI2 ;
UniProt Protein Function:
LIN7B: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface. Belongs to the lin-7 family. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 19q13.3Cellular Component: postsynaptic membrane; neuron projection; tight junction; basolateral plasma membrane; postsynaptic density; synapse; intercellular junctionMolecular Function: protein domain specific bindingBiological Process: asymmetric protein localization; protein transport; exocytosis; neurotransmitter secretion; maintenance of epithelial cell polarity
