The LIN37 Monoclonal Antibody (PAC038466) is a valuable tool for researchers studying LIN37, a key regulator of cell cycle progression and proliferation. This antibody, derived from mouse hybridoma cells, specifically targets LIN37 and is validated for use in various experimental applications, including immunoprecipitation and immunofluorescence.LIN37 is a crucial component of the DREAM complex, which plays a key role in controlling the expression of cell cycle genes and coordinating cell division.
Dysregulation of LIN37 has been linked to various diseases, including cancer, making it an important target for therapeutic interventions. By using the LIN37 Monoclonal Antibody, researchers can gain valuable insights into the function of LIN37 in normal and disease states, aiding in the development of novel treatments and therapies.
Antibody Name:
LIN37 Antibody (PACO38466)
Antibody SKU:
PACO38466
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Protein lin-37 homolog protein (1-246AA)
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO38466 at dilution of 1:100.
Background:
nucleoplasm, G2/M transition of mitotic cell cycle, mitotic cell cycle, regulation of cell cycle
Synonyms:
Protein lin-37 homolog (Antolefinin), LIN37
UniProt Protein Function:
F25965: Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2.Chromosomal Location of Human Ortholog: 19q13.1Cellular Component: nucleoplasm; transcriptional repressor complexMolecular Function: protein bindingBiological Process: G2/M transition of mitotic cell cycle; mitotic cell cycle; regulation of cell cycle
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein expressed in the eye. [provided by RefSeq, Jul 2008]
