LIN28B Rabbit Monoclonal Antibody (CAB9524)
- SKU:
- CAB9524
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | LIN28B Rabbit Monoclonal Antibody |
SKU: | CAB9524 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-163 of human LIN28B (Q6ZN17). |
Sequence: | MAEG GASK GGGE EPGK LPEP AEEE SQVL RGTG HCKW FNVR MGFG FISM INRE GSPL DIPV DVFV HQSK LFME GFRS LKEG EPVE FTFK KSSK GLES IRVT GPGG SPCL GSER RPKG KTLQ KRKP KGDR CYNC GGLD HHAK ECSL PPQP KKCH YCQS IMHM VAN |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 |
Synonyms: | CSDD2; LIN28B |
Positive Sample: | 293T,Hep G2 |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus, nucleolus. |
Calculated MW: | 27kDa |
Observed MW: | 21kDa/32kDa |
The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation.
Purification Method: | Affinity purification |
Gene ID: | 389421 |
Clone Number: | ARC1616 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |