The Lin28B Rabbit Monoclonal Antibody (CAB9524) is a valuable tool for researchers studying Lin28B, a protein involved in regulating gene expression and cellular processes. This antibody, produced in rabbits, exhibits high specificity and sensitivity when detecting Lin28B in human samples, making it suitable for applications such as Western blotting and immunohistochemistry.Lin28B is known for its roles in stem cell maintenance, metabolism regulation, and tumor progression, making it a target of interest in cancer research and regenerative medicine.
By targeting Lin28B, researchers aim to gain insights into its functions and potential therapeutic applications in various diseases.With its ability to specifically target Lin28B, this antibody enables researchers to investigate the expression, localization, and functions of Lin28B in different cell types and tissues. Its use in various research settings, particularly in cancer and stem cell biology, highlights its importance in advancing our understanding of Lin28B's biological roles and potential clinical implications.
Product Name:
LIN28B Rabbit Monoclonal Antibody
SKU:
CAB9524
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-163 of human LIN28B (Q6ZN17).
The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation.
Purification Method:
Affinity purification
Gene ID:
389421
Clone Number:
ARC1616
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using LIN28B Rabbit mAb (CAB9524) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
