The Lin28 Polyclonal Antibody (CAB6034) is a valuable tool for researchers studying Lin28, a protein involved in regulating stem cell differentiation, metabolism, and cancer development. This antibody, generated in rabbits, exhibits high specificity when detecting Lin28 in human samples and has been validated for use in Western blot applications.Lin28 is known for its role in modulating the self-renewal and differentiation of stem cells, making it a key player in developmental biology and regenerative medicine research.
Additionally, Lin28 has been implicated in the progression of various cancers, highlighting its potential as a therapeutic target for cancer treatment.By using the Lin28 Polyclonal Antibody, researchers can effectively detect and analyze Lin28 protein levels in a variety of cell types, providing valuable insights into its function and potential implications in disease pathology. This antibody is an essential tool for studies focusing on stem cell biology, cancer research, and other related fields.
Product Name:
LIN28 Rabbit Polyclonal Antibody
SKU:
CAB6034
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-209 of human LIN28A (NP_078950.1).
This gene encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. The encoded protein functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development. This protein prevents the terminal processing of the LET7 family of microRNAs which are major regulators of cellular growth and differentiation. Aberrant expression of this gene is associated with cancer progression in multiple tissues.
Purification Method:
Affinity purification
Gene ID:
79727
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from T47D cells, using LIN28A Rabbit pAb (CAB6034) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
