LIMS1 Rabbit Polyclonal Antibody (CAB13917)
- SKU:
- CAB13917
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | LIMS1 Rabbit Polyclonal Antibody |
SKU: | CAB13917 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-325 of human LIMS1 (NP_001180417.1). |
Sequence: | MANA LASA TCER CKGG FAPA EKIV NSNG ELYH EQCF VCAQ CFQQ FPEG LFYE FEGR KYCE HDFQ MLFA PCCH QCGE FIIG RVIK AMNN SWHP ECFR CDLC QEVL ADIG FVKN AGRH LCRP CHNR EKAR GLGK YICQ KCHA IIDE QPLI FKND PYHP DHFN CANC GKEL TADA RELK GELY CLPC HDKM GVPI CGAC RRPI EGRV VNAM GKQW HVEH FVCA KCEK PFLG HRHY ERKG LAYC ETHY NQLF GDVC FHCN RVIE GDVV SALN KAWC VNCF ACST CNTK LTLK NKFV EFDM KPVC KKCY EKFP LELK KRLK KLAE TLGR K |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | PINCH; PINCH1; PINCH-1; LIMS1 |
Positive Sample: | Mouse heart |
Conjugate: | Unconjugated |
Cellular Localization: | Cell junction, Cell membrane, Cytoplasmic side, Peripheral membrane protein, focal adhesion. |
Calculated MW: | 37kDa |
Observed MW: | 37kDa |
The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 3987 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |