LIMK1 Rabbit Polyclonal Antibody (CAB16664)
- SKU:
- CAB16664
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | LIMK1 Rabbit Polyclonal Antibody |
SKU: | CAB16664 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 510-647 of LIMK1 (NP_002305.1). |
Sequence: | VGNP YWMA PEMI NGRS YDEK VDVF SFGI VLCE IIGR VNAD PDYL PRTM DFGL NVRG FLDR YCPP NCPP SFFP ITVR CCDL DPEK RPSF VKLE HWLE TLRM HLAG HLPL GPQL EQLD RGFW ETYR RGES GLPA HPEV PD |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | LIMK; LIMK-1; LIMK1 |
Positive Sample: | HeLa,A-431,Mouse brain,NIH/3T3,Rat lung,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 73kDa |
Observed MW: | 73kDa |
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Purification Method: | Affinity purification |
Gene ID: | 3984 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |