The LILRB5 Polyclonal Antibody (PACO63675) is a valuable tool for researchers studying LILRB5, a member of the leukocyte immunoglobulin-like receptor (LILR) family known for its role in immune regulation. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting LILRB5 in human samples, particularly in Western blot applications.LILRB5, also referred to as leukocyte immunoglobulin-like receptor subfamily B member 5, is involved in modulating immune responses, including inhibiting activation of immune cells and regulating inflammatory processes.
Its dysregulation has been linked to various diseases, such as cancer, autoimmune disorders, and inflammatory conditions, making it a promising target for therapeutic interventions.By utilizing the LILRB5 Polyclonal Antibody, researchers can easily detect and quantify LILRB5 expression in different cell types, providing valuable insights into its function and potential implications in disease pathogenesis. This antibody is essential for advancing our understanding of immune regulation and developing novel treatment strategies for immune-related disorders.
Antibody Name:
LILRB5 Antibody (PACO63675)
Antibody SKU:
PACO63675
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Leukocyte immunoglobulin-like receptor subfamily B member 5 protein (24-350AA)
IHC image of PACO63675 diluted at 1:100 and staining in paraffin-embedded human ovarian cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
May act as receptor for class I MHC antigens.
Synonyms:
Leukocyte immunoglobulin-like receptor subfamily B member 5 (CD85 antigen-like family member C) (Leukocyte immunoglobulin-like receptor 8) (LIR-8) (CD antigen CD85c), LILRB5, LIR8
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Several other LIR subfamily B receptors are expressed on immune cells where they bind to MHC class I molecules on antigen-presenting cells and inhibit stimulation of an immune response. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
