LILRB4 Rabbit Polyclonal Antibody (CAB7073)
- SKU:
- CAB7073
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Product Name: | LILRB4 Rabbit Polyclonal Antibody |
SKU: | CAB7073 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-259 of human LILRB4 (NP_001265355.2). |
Sequence: | QAGP LPKP TLWA EPGS VISW GNSV TIWC QGTL EARE YRLD KEES PAPW DRQN PLEP KNKA RFSI PSMT EDYA GRYR CYYR SPVG WSQP SDPL ELVM TGAY SKPT LSAL PSPL VTSG KSVT LLCQ SRSP MDTF LLIK ERAA HPLL HLRS EHGA QQHQ AEFP MSPV TSVH GGTY RCFS SHGF SHYL LSHP SDPL ELIV SGSL EGPR PSPT RSVS TAAG PEDQ PLMP TGSV PHSG LRRH WE |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | B4; ILT3; LIR5; CD85K; ILT-3; LIR-5; LILRB4 |
Positive Sample: | A-549,MCF7,THP-1,RAW264.7,Mouse lung,Mouse spleen,Rat lung |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Single-pass type I membrane protein. |
Calculated MW: | 49kDa |
Observed MW: | 49kDa |
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 11006 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |