The LILRB4 Polyclonal Antibody (CAB7073) is a valuable tool for researchers studying leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4), a cell surface molecule involved in immune regulation. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the LILRB4 protein, this antibody allows for the detection and analysis of LILRB4 in various cell types, making it ideal for studies in immunology, cancer research, and beyond.LILRB4, also known as immunoglobulin-like transcript 3 (ILT3), plays a key role in immune response modulation by inhibiting immune activation and promoting immune tolerance.
Its involvement in immune regulation makes it a promising target for research into diseases such as cancer, autoimmune disorders, and inflammatory conditions. Understanding the function of LILRB4 is essential for developing therapies that modulate immune responses in these disease contexts, making the LILRB4 Polyclonal Antibody an invaluable tool for researchers in the field.
Product Name:
LILRB4 Rabbit Polyclonal Antibody
SKU:
CAB7073
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 22-259 of human LILRB4 (NP_001265355.2).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
49kDa
Observed MW:
49kDa
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
11006
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using LILRB4 Rabbit pAb (CAB7073) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
