The LILRB3 Polyclonal Antibody (CAB16103) is a valuable tool for studying LILRB3, a member of the leukocyte immunoglobulin-like receptor family involved in immune regulation. This antibody, produced in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot applications. By binding to the LILRB3 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it a versatile tool for research in immunology and cancer.LILRB3, also known as leukocyte immunoglobulin-like receptor subfamily B member 3, plays a crucial role in immune response modulation by regulating immune cell activation and function.
Its involvement in immune signaling pathways makes it a promising target for studying diseases such as cancer, autoimmune disorders, and inflammatory conditions. Understanding the function of LILRB3 is essential for developing novel therapeutic strategies that target immune dysregulation in these disease contexts.Overall, the LILRB3 Polyclonal Antibody is a valuable asset for researchers looking to delve deeper into the role of LILRB3 in immune regulation and disease pathogenesis. Its high reactivity and specificity make it a reliable tool for conducting in-depth studies and advancing our understanding of immune modulation mechanisms.
Product Name:
LILRB3 Rabbit Polyclonal Antibody
SKU:
CAB16103
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 400-500 of human LILRB3 (NP_001307889.1).
Cell membrane, Single-pass type I membrane protein
Calculated MW:
69kDa
Observed MW:
69kDa
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
11025
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Jurkat cells, using LILRB3 Rabbit pAb (CAB16103) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
