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LILRB2 Rabbit Polyclonal Antibody (CAB10135)

SKU:
CAB10135
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology
$167 - $503
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:LILRB2 Rabbit Polyclonal Antibody
SKU:CAB10135
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 22-240 of human LILRB2/CD85d/ILT4 (NP_005865.3).
Sequence:QTGT IPKP TLWA EPDS VITQ GSPV TLSC QGSL EAQE YRLY REKK SASW ITRI RPEL VKNG QFHI PSIT WEHT GRYG CQYY SRAR WSEL SDPL VLVM TGAY PKPT LSAQ PSPV VTSG GRVT LQCE SQVA FGGF ILCK EGED EHPQ CLNS QPHA RGSS RAIF SVGP VSPN RRWS HRCY GYDL NSPY VWSS PSDL LELL VPGV SKKP SLSV QPGP VMAP GES
Tested Applications:WB ELISA
Recommended Dilution:WB,1:1000 - 1:4000
Synonyms:ILT4; LIR2; CD85D; ILT-4; LIR-2; MIR10; MIR-10; LILRB2/CD85d/ILT4
Positive Sample:Mouse liver,Mouse kidney,Mouse blood cell,Rat liver,Rat kidney,Rat blood cell
Conjugate:Unconjugated
Cellular Localization:Membrane, Single-pass type I membrane protein.
Calculated MW:65kDa
Observed MW:65kDa

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.

Purification Method:Affinity purification
Gene ID:10288
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of various cell lines, using LILRB2/CD85d/ILT4 antibody (CAB10135) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.

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