The LILRB1 Polyclonal Antibody (CAB12827) is specifically designed for research involving LILRB1, also known as leukocyte immunoglobulin-like receptor B1. LILRB1 is a cell surface molecule that plays a crucial role in immune regulation by inhibiting immune responses. This antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in Western blot applications. By binding to the LILRB1 protein, this antibody enables researchers to detect and analyze LILRB1 in various cell types, making it ideal for studies in immunology and cancer research.
LILRB1 is an important immune checkpoint receptor that is implicated in immune tolerance and suppression. Its role in modulating immune responses makes it a valuable target for research into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. Understanding the function of LILRB1 is crucial for the development of therapies that aim to harness or modulate immune function in these disease contexts.
Product Name:
LILRB1 Rabbit Polyclonal Antibody
SKU:
CAB12827
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 350-460 of human LILRB1 (Q8NHL6).
Membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:
71kDa
Observed MW:
110kDa
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
10859
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using LILRB1 Rabbit pAb (CAB12827) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
