The LILRA5 Polyclonal Antibody (PAC010252) is a valuable tool for researchers studying the LILRA5 protein, a member of the leukocyte immunoglobulin-like receptor (LILR) family that plays a role in immune regulation. This antibody, raised in rabbits, has been validated for use in various applications, including Western blotting, immunofluorescence, and immunohistochemistry.LILRA5 is known to have both activating and inhibitory functions in immune responses, making it a key player in the modulation of immune cell activity. Studies have shown that dysregulation of LILRA5 expression may be associated with autoimmune diseases, inflammatory conditions, and cancer, highlighting its potential as a therapeutic target.
By using the LILRA5 Polyclonal Antibody, researchers can accurately detect and analyze LILRA5 expression in different cell types, providing valuable insights into its role in immune regulation. This antibody is a valuable tool for advancing our understanding of immune responses and developing targeted therapies for a range of diseases.
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5;LILRA5;CD85;CD85F;ILT11;LILRB7;LIR9 ;
UniProt Protein Function:
LILRA5: May play a role in triggering innate immune responses. Does not seem to play a role for any class I MHC antigen recognition. 4 isoforms of the human protein are produced by alternative splicingChromosomal Location of Human Ortholog: 19q13.4
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family. LIR family members are known to have activating and inibitory functions in leukocytes. Crosslink of this receptor protein on the surface of monocytes has been shown to induce calcium flux and secretion of several proinflammatory cytokines, which suggests the roles of this protein in triggering innate immune responses. This gene is one of the leukocyte receptor genes that form a gene cluster on the chromosomal region 19q13.4. Four alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
