The Lilra3 Polyclonal Antibody (PACO58324) is a crucial tool for researchers studying Lilra3, a cell surface molecule with significant implications in immune regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the Lilra3 protein, this antibody enables the detection and analysis of Lilra3 in various cell types, making it an essential asset for studies in immunology and cancer research.Lilra3, also known as immune inhibitory receptor, plays a vital role in immune homeostasis by regulating inflammatory responses and inhibiting allergic reactions.
Its involvement in immune response modulation positions it as a promising target for research into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. A better understanding of Lilra3 activity is crucial for developing therapies that can either harness or modulate immune function in these disease contexts.Overall, the Lilra3 Polyclonal Antibody (PACO58324) offers researchers a reliable tool for investigating the functions and potential therapeutic implications of Lilra3 in various disease settings, ultimately contributing to the advancement of immunology and cancer research.
Western Blot. Positive WB detected in: A549 whole cell lysate, Jurkat whole cell lysate. All lanes: LILRA3 antibody at 4.2µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 48, 41, 50 kDa. Observed band size: 48 kDa.
IHC image of PACO58324 diluted at 1:300 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
Acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-α production by monocytes.
Synonyms:
Leukocyte immunoglobulin-like receptor subfamily A member 3 (CD85 antigen-like family member E) (Immunoglobulin-like transcript 6) (ILT-6) (Leukocyte immunoglobulin-like receptor 4) (LIR-4) (Monocyte inhibitory receptor HM43/HM31) (CD antigen CD85e), LILRA3, ILT6 LIR4
UniProt Protein Function:
LILRA3: May act as soluble receptor for class I MHC antigens.Protein type: Secreted, signal peptide; SecretedChromosomal Location of Human Ortholog: 19q13.4Cellular Component: plasma membraneMolecular Function: antigen binding; receptor activityBiological Process: defense response; signal transduction
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of a family of immunoreceptors that are expressed predominantly in monocytes and B cells, and at lower levels in dendritic cells and natural killer cells. The encoded protein lacks the transmembrane region found in other members of this family. It acts as a soluble receptor for class I major histocompatibility complex (MHC) antigens. Alternatively spliced transcript variants encoding different isoforms have been found. This gene is located in a cluster of related genes on chromosome 19 and is polymorphic in human populations, with many individuals containing a deletion of this genomic region. [provided by RefSeq, Mar 2014]
