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Anti-LHX8 Antibody (CAB2046)

SKU:
CAB2046
Product Type:
Antibody
Reactivity:
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling
€139 - €419
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Description

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Anti-LHX8 Antibody (CAB2046)

The LHX8 Polyclonal Antibody (CAB2046) is a versatile tool for research involving LHX8, a transcription factor known for its role in regulating gene expression during development. This antibody, produced in rabbits, exhibits high specificity and sensitivity for human samples, making it an ideal choice for Western blot applications. By targeting the LHX8 protein, researchers can easily detect and analyze its expression in various cell types, providing valuable insights into cellular differentiation and tissue development processes.LHX8 is a key player in the regulation of embryonic development, particularly in the formation of various tissues and organs. Its involvement in controlling gene expression patterns makes it a crucial target for studying developmental biology and stem cell differentiation.

Furthermore, dysregulation of LHX8 has been associated with certain genetic disorders and developmental abnormalities, highlighting the importance of understanding its function in both normal and pathological conditions.Overall, the LHX8 Polyclonal Antibody offers researchers a reliable tool for investigating the intricate mechanisms of gene regulation and development, with potential applications in fields such as stem cell research, regenerative medicine, and developmental biology. By accurately detecting and analyzing LHX8 expression, this antibody contributes to advancing our understanding of complex biological processes and may pave the way for novel therapeutic strategies in the future.

Antibody Name:Anti-LHX8 Antibody
Antibody SKU:CAB2046
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human LHX8 (NP_001001933.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse brain, Mouse testis, Mouse ovary, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human LHX8 (NP_001001933.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MQIL SRCQ GLMS EECG RTTA LAAG RTRK GAGE EGLV SPEG AGDE DSCS SSAP LSPS SSPR SMAS GSGC PPGK CVCN SCGL EIVD KYLL KVND LCWH VRCL SCSV CRTS LGRH TSCY IKDK DIFC KLDY FRRY GTRC SRCG RHIH STDW VRRA KGNV YHLA CFAC FSCK RQLS TGEE FALV EEKV LCRV HYDC MLDN LKRE VENG NGIS VEGA LLTE QDVN
Gene ID:431707
Uniprot:Q68G74
Cellular Location:Nucleus
Calculated MW:38kDa/39kDa
Observed MW:39kDa
Synonyms:LHX8, LHX7
Background:The protein encoded by this gene is a member of the LIM homeobox family of proteins, which are involved in patterning and differentiation of various tissue types. These proteins contain two tandemly repeated cysteine-rich double-zinc finger motifs known as LIM domains, in addition to a DNA-binding homeodomain. This family member is a transcription factor that plays a role in tooth morphogenesis. It is also involved in oogenesis and in neuronal differentiation. This gene is a candidate gene for cleft palate, and it is also associated with odontoma formation. Alternative splicing of this gene results in multiple transcript variants.
UniProt Protein Function:LHX8: Transcription factor involved in differentiation of certain neurons and mesenchymal cells.
UniProt Protein Details:

Protein type:DNA-binding; Transcription factor; Cell development/differentiation

Chromosomal Location of Human Ortholog: 1p31.1

Cellular Component: female germ cell nucleus

Molecular Function:zinc ion binding; sequence-specific DNA binding

Biological Process: learning and/or memory; regulation of transcription, DNA-dependent; transcription, DNA-dependent; forebrain neuron development; female gonad development; odontogenesis of dentine-containing teeth

NCBI Summary:The protein encoded by this gene is a member of the LIM homeobox family of proteins, which are involved in patterning and differentiation of various tissue types. These proteins contain two tandemly repeated cysteine-rich double-zinc finger motifs known as LIM domains, in addition to a DNA-binding homeodomain. This family member is a transcription factor that plays a role in tooth morphogenesis. It is also involved in oogenesis and in neuronal differentiation. This gene is a candidate gene for cleft palate, and it is also associated with odontoma formation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
UniProt Code:Q68G74
NCBI GenInfo Identifier:296434566
NCBI Gene ID:431707
NCBI Accession:Q68G74.2
UniProt Related Accession:Q68G74
Molecular Weight:
NCBI Full Name:LIM/homeobox protein Lhx8
NCBI Synonym Full Names:LIM homeobox 8
NCBI Official Symbol:LHX8  
NCBI Official Synonym Symbols:LHX7  
NCBI Protein Information:LIM/homeobox protein Lhx8
UniProt Protein Name:LIM/homeobox protein Lhx8
Protein Family:LIM/homeobox protein
UniProt Gene Name:LHX8  
UniProt Entry Name:LHX8_HUMAN
Anti-LHX8 Antibody (CAB2046)Western blot analysis of extracts of various cell lines, using LHX8 antibody (CAB2046) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.

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