The LHCGR Polyclonal Antibody is a valuable tool for researchers studying the human luteinizing hormone/choriogonadotropin receptor (LHCGR), a key protein involved in reproductive biology. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting LHCGR in a variety of sample types, including cell lysates and tissue sections. Validated for use in Western blot and immunohistochemistry applications, this antibody allows for precise and accurate analysis of LHCGR expression in different cell types and tissues.The LHCGR, a G protein-coupled receptor, plays a critical role in the regulation of reproductive hormones and processes, such as ovulation and steroidogenesis. Dysregulation of LHCGR function has been implicated in various reproductive disorders, including infertility and ovarian hyperstimulation syndrome.
By studying the expression and activity of LHCGR, researchers can gain valuable insights into the underlying mechanisms of these conditions and potentially identify novel therapeutic targets for intervention.Overall, the LHCGR Polyclonal Antibody is a reliable tool for investigating the role of LHCGR in reproductive biology and related disorders. Its high specificity and versatility make it an essential reagent for researchers interested in understanding the molecular mechanisms governing reproductive processes and developing targeted therapies for reproductive disorders.
Product Name:
LHCGR Polyclonal Antibody
SKU:
CAB24884
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human LHCGR（NP_000224.2）.
This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate adenylate cyclase. Mutations in this gene result in disorders of male secondary sexual character development, including familial male precocious puberty, also known as testotoxicosis, hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty, and male pseudohermaphtoditism with Leydig cell hypoplasia.
Purification Method:
Affinity purification
Gene ID:
3973
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse ovary using LHCGR Rabbit pAb(CAB24884) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
