The LHCGR Polyclonal Antibody (CAB6266) is a valuable tool for research involving the luteinizing hormone/choriogonadotropin receptor (LHCGR), a crucial protein involved in reproductive processes. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the LHCGR protein, this antibody enables accurate detection and analysis in various cell types, making it ideal for investigations in reproductive biology and fertility research.The LHCGR receptor is essential for the regulation of reproductive hormones and plays a vital role in processes such as ovulation, implantation, and pregnancy.
Dysregulation of LHCGR function has been linked to infertility, polycystic ovarian syndrome (PCOS), and other reproductive disorders, making it a key target for studies in reproductive medicine. Understanding the mechanisms underlying LHCGR activity is crucial for developing novel treatments and interventions for these conditions, ultimately improving the outcomes for patients struggling with infertility and related reproductive health issues.
Product Name:
LHCGR Rabbit Polyclonal Antibody
SKU:
CAB6266
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 200-360 of human LHCGR (NP_000224.2).
This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate adenylate cyclase. Mutations in this gene result in disorders of male secondary sexual character development, including familial male precocious puberty, also known as testotoxicosis, hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty, and male pseudohermaphtoditism with Leydig cell hypoplasia.
Purification Method:
Affinity purification
Gene ID:
3973
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using LHCGR antibody (CAB6266) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
