Legumain (LGMN) Rabbit Polyclonal Antibody (CAB10570)
- SKU:
- CAB10570
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | Legumain (LGMN) Rabbit Polyclonal Antibody |
SKU: | CAB10570 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-288 of human Legumain (LGMN) (NP_005597.3?). |
Sequence: | GGKH WVVI VAGS NGWY NYRH QADA CHAY QIIH RNGI PDEQ IVVM MYDD IAYS EDNP TPGI VINR PNGT DVYQ GVPK DYTG EDVT PQNF LAVL RGDA EAVK GIGS GKVL KSGP QDHV FIYF TDHG STGI LVFP NEDL HVKD LNET IHYM YKHK MYRK MVFY IEAC ESGS MMNH LPDN INVY ATTA ANPR ESSY ACYY DEKR STYL GDWY SVNW MEDS DVED LTKE TLHK QYHL VKSH TNTS HVMQ YGNK TIST MKVM QFQG MKR |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | AEP; LGMN1; PRSC1; Legumain (LGMN) |
Positive Sample: | Mouse kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Lysosome. |
Calculated MW: | 49kDa |
Observed MW: | 36kDa/55kDa |
This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform.
Purification Method: | Affinity purification |
Gene ID: | 5641 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |