The LGI4 Antibody (PAC058288) is a polyclonal antibody designed for research involving LGI4, a protein involved in synaptic transmission and neurodevelopment. This antibody, raised in rabbits, is highly specific and reactive with human samples, allowing for accurate detection and analysis in various cell types.LGI4 is a member of the leucine-rich glioma inactivated (LGI) family of proteins, known for their role in regulating neuronal activity and synaptic plasticity. LGI4 has been implicated in various neurological disorders, making it a valuable target for research into conditions such as epilepsy, schizophrenia, and autism spectrum disorders.
By using the LGI4 Antibody in Western blot applications, researchers can investigate the expression and function of LGI4 in different cell types and tissues. This antibody enables the study of LGI4's involvement in neuronal signaling pathways and its potential as a therapeutic target for neurological diseases.Overall, the LGI4 Antibody offers researchers a powerful tool for studying the role of LGI4 in neurobiology and advancing our understanding of its impact on brain function and disease pathology.
Antibody Name:
LGI4 Antibody (PACO58288)
Antibody SKU:
PACO58288
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:200-1:500
Species Reactivity:
Human
Immunogen:
Recombinant Human Leucine-rich repeat LGI family member 4 protein (292-412AA)
IHC image of PACO58288 diluted at 1:200 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
IHC image of PACO58288 diluted at 1:200 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
extracellular region
Synonyms:
Leucine-rich repeat LGI family member 4 (LGI1-like protein 3) (Leucine-rich glioma-inactivated protein 4), LGI4, LGIL3
UniProt Protein Function:
LGI4: 2 isoforms of the human protein are produced by alternative splicing.Protein type: Secreted, signal peptide; SecretedChromosomal Location of Human Ortholog: 19q13.12|19q13.11Cellular Component: extracellular spaceBiological Process: glial cell proliferation; adult locomotory behavior; neuron maturation; myelination in the peripheral nervous system
