The LGI1 Polyclonal Antibody (CAB5408) is a valuable tool for researchers studying LGI1, a protein involved in synaptic transmission and epilepsy. Produced in rabbits, this antibody is highly specific to human samples and has been validated for use in Western blot applications. By binding to LGI1, this antibody allows for precise detection and analysis of the protein in various cell types, making it essential for studies in neuroscience and neurological disorders.LGI1 is a secreted protein that plays a crucial role in maintaining neuronal excitability and synaptic transmission. Mutations in LGI1 have been associated with various forms of epilepsy, highlighting its importance in brain function and disease.
Research on LGI1 can provide valuable insights into the mechanisms underlying epilepsy and potentially lead to the development of novel therapies for seizure disorders.With its high specificity and reliability, the LGI1 Polyclonal Antibody (CAB5408) is a valuable tool for researchers aiming to deepen our understanding of LGI1's function and role in neurological disorders. Its application in Western blotting assays ensures accurate and reliable results, making it an indispensable asset for laboratories studying epilepsy and synaptic transmission.
Product Name:
LGI1 Rabbit Polyclonal Antibody
SKU:
CAB5408
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 301-557 of human LGI1 (NP_005088.1).
This gene encodes a member of the secreted leucine-rich repeat (LRR) superfamily and shares homology with members of the SLIT protein family. The encoded protein may regulate the activity of voltage-gated potassium channels and may be involved in neuronal growth regulation and cell survival. This gene is rearranged as a result of translocations in glioblastoma cell lines, and it is frequently down-regulated or rearranged in malignant gliomas. Mutations in this gene result in autosomal dominant lateral temporal epilepsy. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
9211
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using LGI1 Rabbit pAb (CAB5408) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
