The LGI1 Polyclonal Antibody (CAB19230) is a vital tool for researchers studying LGI1, a protein associated with autoimmune encephalitis and epilepsy. This antibody, produced in rabbits, exhibits high specificity and reactivity with human samples, making it an ideal choice for Western blot applications. By targeting the LGI1 protein, this antibody enables accurate detection and analysis in various cell types, facilitating investigations in neurology and autoimmune disease research.
LGI1 is a crucial player in synaptic transmission and neuronal excitability, making it a key target for understanding neurological disorders such as epilepsy and autoimmune encephalitis. Research on LGI1 is essential for uncovering the mechanisms underlying these conditions and developing targeted therapies to treat them effectively. The LGI1 Polyclonal Antibody provides a reliable tool for researchers to further explore the role of LGI1 in health and disease.
Product Name:
LGI1 Rabbit Monoclonal Antibody
SKU:
CAB19230
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 150-250 of human LGI1 (O95970).
This gene encodes a member of the secreted leucine-rich repeat (LRR) superfamily and shares homology with members of the SLIT protein family. The encoded protein may regulate the activity of voltage-gated potassium channels and may be involved in neuronal growth regulation and cell survival. This gene is rearranged as a result of translocations in glioblastoma cell lines, and it is frequently down-regulated or rearranged in malignant gliomas. Mutations in this gene result in autosomal dominant lateral temporal epilepsy. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
9211
Clone Number:
ARC2388
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using LGI1 antibody (CAB19230) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
