LFNG Rabbit Polyclonal Antibody (CAB7441)
- SKU:
- CAB7441
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | LFNG Rabbit Polyclonal Antibody |
SKU: | CAB7441 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human LFNG (NP_002295.1). |
Sequence: | MTPG RCCL AADI QVET FIFT DGED EALA RHTG NVVI TNCS AAHS RQAL SCKM AVEY DRFI ESGR KWFC HVDD DNYV NLRA LLRL LASY PHTR DVYV GKPS LDRP IQAM ERVS ENKV RPVH FWFA TGGA GFCI SRGL ALKM SPWA SGGH FMNT AERI RLPD DCTI GYIV EALL GVPL IRSG LFHS HLEN LQQV PTSE LHEQ VTLS YGMF ENKR NAVH VKGP FSVE ADPS RFRS IHCH LYPD TPWC PRTA IF |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | SCDO3; LFNG |
Positive Sample: | BT-474,SW620,PC-12,HeLa,Mouse spleen,Mouse brain,Mouse lung |
Conjugate: | Unconjugated |
Cellular Localization: | Golgi apparatus membrane, Single-pass type II membrane protein. |
Calculated MW: | 42kDa |
Observed MW: | 42kDa |
This gene is a member of the glycosyltransferase 31 gene family. Members of this gene family, which also includes the MFNG (GeneID: 4242) and RFNG (GeneID: 5986) genes, encode evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, these proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. The protein encoded by this gene is predicted to be a single-pass type II Golgi membrane protein but it may also be secreted and proteolytically processed like the related proteins in mouse and Drosophila (PMID: 9187150). Mutations in this gene have been associated with autosomal recessive spondylocostal dysostosis 3.
Purification Method: | Affinity purification |
Gene ID: | 3955 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |