The Leptin Receptor Rabbit Monoclonal Antibody (CAB19076) is a powerful tool for researchers studying the leptin receptor, a key player in the regulation of energy balance and metabolism. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it an ideal choice for experiments such as Western blotting.The leptin receptor plays a crucial role in the control of appetite and body weight, making it an important target for research in the fields of obesity, diabetes, and metabolism. By binding specifically to the leptin receptor protein, this antibody allows for accurate detection and analysis in various experimental settings, providing valuable insights into the mechanisms underlying metabolic disorders and potential treatment strategies.
With its reliable performance and versatility in detecting the leptin receptor in different cell types, the Leptin Receptor Rabbit Monoclonal Antibody (CAB19076) is a valuable asset for scientists working in the fields of endocrinology, metabolism, and obesity research. Its ability to facilitate the study of leptin receptor function paves the way for advancements in understanding and treating metabolic diseases.
Product Name:
Leptin Receptor Rabbit Monoclonal Antibody
SKU:
CAB19076
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1000-1100 of human Leptin Receptor (P48357).
Cell membrane, Secreted, Single-pass type I membrane protein
Calculated MW:
132kDa
Observed MW:
140kDa
The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).
Purification Method:
Affinity purification
Gene ID:
3953
Clone Number:
ARC0454
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using Leptin Receptor Rabbit mAb (CAB19076) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1min .
