Leptin Receptor Rabbit Polyclonal Antibody (CAB2999)
- SKU:
- CAB2999
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | Leptin Receptor Rabbit Polyclonal Antibody |
SKU: | CAB2999 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1070-1165 of human LEPR (NP_002294.2). |
Sequence: | ENND KKSI YYLG VTSI KKRE SGVL LTDK SRVS CPFP APCL FTDI RVLQ DSCS HFVE NNIN LGTS SKKT FASY MPQF QTCS TQTH KIME NKMC DLTV |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | OBR; OB-R; CD295; LEP-R; LEPRD; Leptin Receptor |
Positive Sample: | Rat lung,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Secreted, Single-pass type I membrane protein. |
Calculated MW: | 132kDa |
Observed MW: | 140kDa |
The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).
Purification Method: | Affinity purification |
Gene ID: | 3953 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |