The Leptin Polyclonal Antibody (CAB5673) is a valuable tool for researchers studying the protein leptin, which plays a key role in regulating energy balance and body weight. This antibody, produced in rabbits, is highly specific and reactive to human samples, making it ideal for use in Western blot applications. By binding to the leptin protein, this antibody allows for accurate detection and analysis of leptin levels in various cell types.Leptin is a hormone produced by adipose tissue that communicates with the brain to regulate food intake and energy expenditure. Dysregulation of leptin signaling has been implicated in obesity, diabetes, and other metabolic disorders.
Therefore, research into leptin and its downstream effects is crucial for understanding the mechanisms underlying these conditions and developing potential therapies.With its high specificity and reactivity, the Leptin Polyclonal Antibody (CAB5673) is a valuable tool for researchers investigating the role of leptin in metabolism, obesity, and related diseases. Its use in Western blot applications allows for precise and reliable detection of leptin levels, making it a valuable asset in the field of metabolic research.
Product Name:
LEP Rabbit Polyclonal Antibody
SKU:
CAB5673
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 22-167 of human Leptin (NP_000221.1).
This gene encodes a protein that is secreted by white adipocytes into the circulation and plays a major role in the regulation of energy homeostasis. Circulating leptin binds to the leptin receptor in the brain, which activates downstream signaling pathways that inhibit feeding and promote energy expenditure. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis, reproduction, bone formation and wound healing. Mutations in this gene and its regulatory regions cause severe obesity and morbid obesity with hypogonadism in human patients. A mutation in this gene has also been linked to type 2 diabetes mellitus development.
Purification Method:
Affinity purification
Gene ID:
3952
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded Human prostate using Leptin Rabbit pAb (CAB5673) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
