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Leptin Receptor Rabbit Monoclonal Antibody (CAB19076)

SKU:
CAB19076
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Leptin Receptor Rabbit Monoclonal Antibody
SKU:CAB19076
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1000-1100 of human Leptin Receptor (P48357).
Sequence:EEQG LINS SVTK CFSS KNSP LKDS FSNS SWEI EAQA FFIL SDQH PNII SPHL TFSE GLDE LLKL EGNF PEEN NDKK SIYY LGVT SIKK RESG VLLT DKSR V
Tested Applications:WB IHC-P ELISA
Recommended Dilution:WB,1:500 - 1:1000 IHC-P,1:50 - 1:200
Synonyms:OBR; OB-R; CD295; LEP-R; LEPRD; Leptin Receptor
Positive Sample:Hep G2,Mouse heart,Mouse lung,Rat liver
Conjugate:Unconjugated
Cellular Localization:Cell membrane, Secreted, Single-pass type I membrane protein
Calculated MW:132kDa
Observed MW:140kDa

The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).

Purification Method:Affinity purification
Gene ID:3953
Clone Number:ARC0454
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using Leptin Receptor Rabbit mAb (CAB19076) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1min .

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