The LEPA Polyclonal Antibody (PACO34594) is a valuable tool for researchers studying LEPA, a highly conserved cytokine involved in various physiological processes. This antibody, generated in rabbits, exhibits high specificity and sensitivity for human samples, making it ideal for use in Western blot applications. By targeting the LEPA protein, this antibody allows for accurate detection and analysis in a variety of cell types, facilitating investigations in the fields of metabolism, obesity, and inflammation.LEPA, also known as leptin, serves as a key regulator of energy balance and body weight through its effects on appetite, metabolism, and adipogenesis.
Dysregulation of LEPA signaling has been linked to obesity, metabolic disorders, and cardiovascular diseases, highlighting its importance as a potential therapeutic target. By exploring the role of LEPA in these pathways, researchers can gain valuable insights into the mechanisms underlying these conditions and identify new strategies for intervention and treatment.
Antibody Name:
lepA Antibody (PACO34594)
Antibody SKU:
PACO34594
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Escherichia coli
Immunogen:
Recombinant Escherichia coli Elongation factor 4 protein (1-599AA)
Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.
Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.
UniProt Protein Details:
NCBI Summary:
Although EF4 improves translational accuracy, it can not reverse paromomycin-induced errors (Qin, 2006). [More information is available at EcoGene: EG10529]. LepA is an elongation factor that induces back-translocation of the ribosome. [More information is available at EcoCyc: EG10529].
