UniProt Protein Function: | Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner. |
UniProt Protein Details: | |
NCBI Summary: | Although EF4 improves translational accuracy, it can not reverse paromomycin-induced errors (Qin, 2006). [More information is available at EcoGene: EG10529]. LepA is an elongation factor that induces back-translocation of the ribosome. [More information is available at EcoCyc: EG10529]. |
UniProt Code: | P60785 |
NCBI GenInfo Identifier: | 16130494 |
NCBI Gene ID: | 947051 |
NCBI Accession: | NP_417064.1 |
UniProt Secondary Accession: | P60785,P07682, P76590, Q2MAG1 |
UniProt Related Accession: | P60785 |
Molecular Weight: | 66,570 Da |
NCBI Full Name: | back-translocating elongation factor EF4, GTPase |
NCBI Synonym Full Names: | |
NCBI Official Symbol: | lepAÂ Â |
NCBI Official Synonym Symbols: | ECK2567; JW2553Â Â |
NCBI Protein Information: | back-translocating elongation factor EF4, GTPase |
UniProt Protein Name: | Elongation factor 4 |
UniProt Synonym Protein Names: | Ribosomal back-translocase LepA |
Protein Family: | Leptin |
UniProt Gene Name: | lepAÂ Â |
UniProt Entry Name: | LEPA_ECOLI |